Iron Deficiency Anemia – Overview and Treatment Options

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iron deficiency anemiaIron deficiency anemia is caused by an iron deficiency in the body. Iron deficiency is the most prevalent nutritional deficiency in the world.1 In the United States it accounts for 5% of anemia cases in women and 2% in men. Anemia (derived from the Greek word ‘anaimia’, meaning ‘lack of blood’) is associated with chronic fatigue, impaired cognitive function, and an overall decreased sense of well-being.

This article will define iron deficiency, explain what causes iron deficiency anemia, and detail treatment options and potential side effects of iron replacement therapy.

 

What Is Iron Deficiency Anemia?

Iron deficiency anemia is a medical condition characterized by low iron levels in the body, which leads to low hemoglobin levels, and, ultimately, a disorder known as anemia. It is the most common cause of anemia. Anemia is a lack of red blood cells or hemoglobin in the body and results in a reduced amount of oxygen transported throughout the body. This causes weakness, fatigue, and cognitive impairment in persons afflicted with this condition.2

The World Health Organization defines anemia by the following hemoglobin (Hgb) values:3

Men – Hgb < 13.0 g/dL
Women (non-pregnant) – Hgb < 12.0 g/dL
Women (pregnant) – Hgb < 11.0 g/dL

 

What Causes Iron Deficiency Anemia?

Iron deficiency anemia has four main possible causes listed below.4-6 If you have one or more of the following four issues below it doesn’t mean you definitely have iron deficiency anemia. It just means that these are the four main potential items that may cause this medical condition. A physician is the only one who can diagnose iron deficiency anemia in you.

4 Main Causes of Iron Deficiency Anemia

  1. Decreased dietary intake of iron (malnutrition or vegan/vegetarian diet)
  2. Decreased absorption of iron in the gut (celiac disease, atrophic gastritis, surgical resection of part or all of the stomach and/or intestines, etc.)
  3. Increased demand for iron (pregnancy, rapid growth during childhood, blood losses)
  4. Increased loss of iron (excessive blood losses in any form)

If you’re diagnosed with iron deficiency anemia it is important to work with your doctor to find the cause of it. Treating iron deficiency anemia with iron supplements without finding the cause only provides a short-term solution, it is not a permanent answer to your problems.

Increased blood losses resulting in iron deficiency can stem from a number of different factors. The most common is due to excessive bleeding during the menstrual cycle in premenopausal females.3 This condition is known as menorrhagia. It’s why women are more susceptible to iron deficiency anemia than men.

In postmenopausal females and men the most common cause of iron deficiency and iron deficiency anemia are disorders involving the gastrointestinal tract.6 These include either a decreased absorption of iron or increased loss of iron due to blood loss.

The most common causes of bleeding disorders in the gut involve:7,8

  • Benign or cancerous tumors of the gastrointestinal tract
  • Hemorrhoids
  • Peptic or duodenal ulcer disease
  • Chronic use of aspirin, non-steroidal anti-inflammatory drugs (ibuprofen, naproxen, etc.), antiplatelet drugs (Plavix, Brilinta, Effient), or anticoagulants (Coumadin, warfarin)
  • Inflammatory bowel disease (ulcerative colitis and Crohn’s disease)
  • Esophageal varices (enlarged, bleeding veins in the esophagus due to liver disease)
  • Diverticular disease
  • Microscopic bleeding due to cow’s milk consumption in infants and toddlers


What is Iron Used For in the Body?

Most people think of bridges, buildings, tools, and machines when they think of iron. After all, iron is used to make all these things. However, the human body has very different uses for iron. These include the following three main items:4,9,10

   
1) Transportation of oxygen throughout the body

  • hemoglobinRed blood cells, and the hemoglobin found inside of them, require iron in their formation process. Without iron they wouldn’t exist. Red blood cells carry oxygen from the lungs to the rest of the body via the blood supply. Each hemoglobin molecule has four iron molecules, and, therefore, can bind a total of four oxygen molecules. Each red blood cell has approximately 270 million hemoglobin molecules. Each person has around 20-30 trillion red blood cells.
  • Myoglobin is similar to hemoglobin but is only found in muscle tissue. It “grabs” the oxygen delivered by the hemoglobin to the muscle tissue. Each myoglobin molecule contains only one iron molecule and can carry or store only one oxygen molecule because of this.

     2) Growth and development

  • Iron deficiency and iron deficiency anemia have both been shown to slow the development of a child’s motor skills and negatively effect their brain from developing normally.

     3) The formation of energy

  • Iron is essential in the formation of more ATP (i.e. energy).


How Much Iron Do You Need?

The average human adult stores about 1-3 grams (1,000-3000mg) of iron in their body.4 There is no known mechanism for the human body to get rid of excess iron. The body does lose a very small amount of iron per day through sweat, urine, and stool though. These losses amount to approximately 1mg of iron per day. In reproductive females, an additional 1mg of iron per day on average is lost in the menstrual blood.

The human requirements for iron replacement involve replacing these daily losses of iron. This is equivalent to 1-2 mg per day of iron. The body needs so little replacement iron because it recycles most of the iron it uses. This iron is stored primarily in the liver, spleen, and bone marrow. Children may require a little more replacement iron for growth and development purposes. And pregnant mothers will require more for their growing baby. Below you’ll find the daily iron requirements for different age and gender groups according to the World Health Organization.

Daily Iron Requirements for 97.5% of the Population4

  • Children (4 months to 5 years) – 0.61-0.96 mg
  • Children (6-11 years) – 1.17mg
  • Male adolescents (12-16 years) – 1.82mg
  • Female adolescents (12-16 years) – 2.02mg
  • Adults (males and postmenopausal females) – 0.9-0.96mg
  • Adults (non-pregnant, premenopausal females) – 2.38mg
  • Adults (females, first trimester) – 0.8
  • Adults (females, second and third trimester) – 6.3mg
  • Adults (lactating females) – 1.31mg


Where Does Iron Come From In the Diet?

There are two different forms of iron obtained in the diet – heme iron and non-heme iron.5 Heme iron is absorbed more readily by the human digestive system. Heme iron is only found in animal foods, mainly in meat (beef, chicken, pork, lamb, turkey, fish, seafood). Even though heme iron is better absorbed than non-heme iron it has been linked to an increased risk in several types of cancers including colon, stomach, esophageal, and endometrial cancers.11-13

Non-heme iron is mostly found in plant foods, but is also present in animal foods like dairy and eggs. It is typically obtained by eating vegetables, legumes, wholes grains, fortified cereals, and a few other plant foods.

Humans absorb very little iron on the whole from dietary sources. Heme iron is absorbed at about a 15%-35% rate, whereas non-heme iron is absorbed at a rate of approximately 2%-20%.4 On average, the typical Western diet contains roughly 7mg of iron per 1,000 calories consumed.1 So, if you were to consume a Western diet of 2,000 calories per day then this would be equal to 14mg of iron per day. Remember though, only a fraction of this is absorbed in the digestive tract. It is usually still enough to meet the 1-2 mg/day that most people require to replace their daily iron losses.

Vegans and vegetarians consume the same or more iron each day. A study published in 2014 showed that on average vegans consumed 23 mg of iron per day and vegetarians consumed 20 mg/day.14 Omnivores, pesco-vegetarians, and semi-vegetarians consumed an average of 17-20 mg of iron each day in this study.

Despite the common myth that vegans and vegetarians are more likely to be iron deficient and anemic, they are not. The Position of the American Dietetic Association pointed this out in 2009 stating, “Incidence of iron-deficiency anemia among vegetarians is similar to that of non-vegetarians. Although vegetarian adults have lower iron stores than non-vegetarians, their serum ferritin levels are usually within the normal range.”15

 

How Can I Increase My Iron Levels?

If you find yourself diagnosed with iron deficiency or iron deficiency anemia then obviously you need to increase your iron levels. You also need to work with your doctor to find the cause of your condition.

Obtaining more iron through dietary sources is preferred, especially through healthy plant foods. There are no side effects to eating vegetables! This is the safest way to increase your iron stores if only a minor deficiency exists. But for those with iron deficiency anemia an iron replacement supplement may be in order.

Before you do anything though please remember to never take iron supplements unless your doctor tells you to. Do not self-diagnose yourself with iron deficiency anemia and start taking iron supplements over the counter because you feel tired or worn out. Supplementing with this metal can be potentially toxic so please do not do it on your own.

Iron Content In Dietary Sources

With that in mind let’s take a look at the iron content in various food items. Below is a chart with this information.16 Animal foods are listed in red and plant foods are listed in green. Remember again, only a small portion of the iron content listed is actually absorbed.

iron content in animal foods

iron content in plant foods

One positive note on iron deficiency anemia is that when an individual is anemic the body can compensate to allow more iron to be absorbed from the diet. This is one of our body’s innate mechanisms to try and fix the condition at hand. When this happens the digestive tract allows up to 20-40mg/day of iron to be absorbed instead of the normal 1-2mg/day.5

Another way to increase iron absorption in the diet is to consume iron-rich plant foods with vitamin C or vitamin C containing foods (i.e. citrus, fruit juices, strawberries, green leafy vegetables, cauliflower, cabbage, etc.).5 Some cooked, fermented or germinated foods and condiments like sauerkraut and soy sauce can also increase iron absorption.

Other food items may inhibit iron absorption. These include phytates found in legumes, nuts, and seeds. Tannin-rich foods such as coffee and tea can also inhibit iron absorption. And lastly, calcium-containing foods or antacids can decrease iron absorption. These items should all be separated from iron-rich foods by at least a couple of hours.

 

Iron Supplementationiron supplements

If you find yourself needing iron supplementation per your physician’s recommendation then there are a few different types of iron supplements to choose from.17

 

     1)  Ferrous iron salts (ferrous sulfate, ferrous
gluconate, ferrous fumurate)

  • Typical first-line iron replacement supplements (especially ferrous sulfate) due to their low cost, general tolerability, and effectiveness

     2)  Ferric irons (ferric ammonium citrate, polysaccharide-iron complex)

  • These iron products are three times less readily absorbed than the ferrous salt forms of iron with the exception of the polysaccharide iron complex which has similar absorption rates to ferrous sulfate

    3)  Carbonyl iron

  • Consists of 100% elemental iron
  • Less toxic than iron salts

    4)  Iron-amino acid chelates (ferrous bisglycinate, etc.)

  • High bioavailability (better absorbed) than ferrous or ferric forms of iron
  • Less GI intolerance than other forms of iron
  • Deva Nutrition makes a vegan chelated iron product if interested

    5)  Heme-iron polypeptide

  • Better absorbed and better tolerated than iron salts
  • Derived from pork red blood cells

For a more detailed report of these different forms of iron please read an article discussing this more in depth on the Pharmacist’s Letter here.

When taking oral iron supplements it is important to avoid antacids and to take the iron supplements on an empty stomach. Both of these actions will improve iron absorption, although the GI side effects may increase by taking iron on an empty stomach. Food actually decreases iron absorption by 40%-50%.17

GI intolerance (nausea, vomiting, abdominal pain/discomfort, constipation, dark colored stools) can be the most troubling side effects for those taking oral iron supplementation and occurs in approximately 30%-43% of patients on the ferrous salt forms of iron.18 Up to 50% of patients will stop taking their iron supplement because of these unpleasant side effects.3

The goal of taking oral iron replacement therapy in iron deficiency anemia is obviously to restore the iron stores in the body and to bring a person’s hemoglobin up to normal levels. Hemoglobin levels should start to rise after 1-2 weeks and should increase approximately 1 gm/week with proper oral iron replacement therapy. After four weeks, those with a minor iron deficiency may get their hemoglobin levels back to normal, but some individuals may take longer.19 It takes even longer to replenish iron stores back to normal in the body. This process can take up to 3-6 months of iron therapy.

In people who cannot tolerate oral iron therapy, or for those with severe anemia requiring faster iron replacement, there are IV forms of iron available. These are more expensive, require more healthcare resources and medical staff to administer and monitor the iron replacement infusion therapy, and have the potential to cause rare, but life-threatening, allergic reactions in some patients. Therefore, using intravenous iron infusion therapy should be discussed thoroughly with your doctor before proceeding.


Conclusions

Iron deficiency anemia is a serious medical condition requiring targeted goal therapies. Patients should work diligently with their doctor to find the cause of their condition while also treating with iron replacement therapy.

Diet is always a good place to start when trying to increase iron intake and may even be part of the cause. Many of the conditions talked about in this article that lead to decreased iron absorption or an increase in iron loss through bleeding are due in part or in full to diet—celiac disease, inflammatory bowel disease, diverticular disease, abnormal menstrual bleeding, hemorrhoids, colon cancer, etc. By adopting a whole foods, plant-based diet you may be able to eliminate or decrease the damage done by many of these diseases, and, in the process, treat your iron deficiency anemia.

Some people will need to take iron supplements though if medically indicated by their physician. Iron and hemoglobin levels will need to be monitored while doing this so make sure to work closely with your doctor to ensure you are taking the right dose of iron. In the end, iron deficiency can be easily treated with the right guidance and plan of action.

May life bring you an abundance of health and happiness in your journey towards optimal health!

Plant-Based Pharmacist

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